Nature

Amino acid composition drives aggregation during peptide synthesis

Peptide aggregation is a long-standing challenge in chemical peptide synthesis, limiting its efficiency and reliability. Although data-driven methods have enhanced our understanding of many ...
C&EN

Espresso Coffee Mitigates the Aggregation and Condensation of Alzheimer′s Associated Tau Protein

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Espresso coffee is among the most consumed beverages in the world. Recent studies ...
C&EN

Modulation of α-Synuclein Aggregation In Vitro by a DNA Aptamer

Program in Biomolecular Sciences and Engineering, Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, United States Program in Biomolecular Sciences ...
Frontiers

Protein Aggregation as a Bacterial Strategy to Survive Antibiotic Treatment

While protein aggregation is predominantly associated with loss of function and toxicity, it is also known to increase survival of bacteria under stressful conditions. Indeed, protein aggregation not ...
Nature

On the Aggregation and Nucleation Mechanism of the Monoclonal Antibody Anti-CD20 Near Liquid-Liquid Phase Separation (LLPS)

The crystallization of Anti-CD20, a full-length monoclonal antibody, has been studied in the PEG400/Na 2 SO 4 /Water system near Liquid-Liquid Phase Separation (LLPS) conditions by both sitting-drop ...
Frontiers

CD95 Structure, Aggregation and Cell Signaling

CD95 is a pre-ligand-associated transmembrane (TM) receptor. The interaction with its ligand CD95L brings to a next level its aggregation and triggers different signaling pathways, leading to cell ...